119-65-3 Isoquinoline Alkaloids Medical Intermediate Make Drugs And Insecticide , Light Yellow Oily Liquid

Quick Detail:

A colorless crystalline, with a variety of miscible organic solvents, soluble in diluted acid; with water, alkaline quinoline; similar to anise oil and benzene ether smell.

Description:

A colorless crystalline or liquid sheet. Melting point 26.48 , 242.2 boiling point (99.1kPa), the relative density of 1.09101 (30/4 ), refractive index 1.62078 (30 ), flash is 107 . With a variety of miscible organic solvents, soluble in diluted acid. With water, alkaline quinoline strong. A similar oil of anise and anisole smell.

With the steam can be volatile. After storage, the color yellow. PKa=5.4, alkaline slightly stronger than quinoline, can become a salt and acid: its hydrochloride, melting point 209 , melting point 223 picrate. N can occur acylation and alkylation reaction, its melting point is 159 methiodide. Electrophilic substitution occurs in 5 bit or 8 bit. Nucleophilic substitution occurred in the 1. Oxidation and reduction reactions occur easily. Found in coal tar, making available than Zeller - Na Pierre Lars Ki synthesis or Pomerantz Selfridge reaction. Containing isoquinoline ring some important alkaloids.

Isoquinoline content (and water) chromatography,%, not less than 95 water,% of not more than 0.5;

The production method:

Quinoline isoquinoline 83%; 15%; crude quinoline methyl quinoline isoquinoline 2% can be used as a resource, but is generally in the crude quinoline distillation cut 237.5-239.5 segment, continue to cut 243-246 fraction as raw material, extraction of isoquinoline. This fraction in the hydrochloride form partially isolated 2- methyl quinoline quinoline about 3.9% 13-28%. The isoquinoline fractions in alcohol solution with 98% sulfuric acid at 35% reaction of isoquinoline sulfonate, cooling, isoquinoline sulfonate homologues sulfonate than it first crystallization. After filtering, re crystallization with 85% ethanol, then 20% ammonia decomposition, reservoir water washing generated after distillation cut 242-243 fraction, is isoquinoline purity greater than 95%.

Applications:

 Can manufacture drugs and insecticide, oxidation can be made after the pyridine carboxylic acid, its derivative can be used in the manufacture of color film and dye. Used as intermediate and gas synthetic drugs, dyes, pesticides GC stationary liquid.

Specifications:

name:Isoquinoline
1.cas:119-65-3
2.appearance:Light yellow oily liquid
3.Content:95% min , 96% min, 97% min ,98% min

                     Isoquinoline